In relation to DM1, pentamidine treatment of a HeLa DM1 cell model transiently expressing r(CUG)960 revealed a reduction in MBNL:r(CUG)EXP foci and the rescue of INSR exon 11 and cardiac troponin T (cTNT) exon 5 MBNL-dependent minigene mis-splicing events [35]. The gene discussed is INSR; the disease is myotonic dystrophy type 1.