To confirm the selective involvement of HIF-2α, but not that of HIF-1α, in the H19 downregulation, we evaluated changes in the H19 response to combined treatment in the VHL-deficient renal carcinomas cells (786-O) that express endogenous HIF-2α, but not HIF-1α [46,47]. The gene discussed is HIF1A; the disease is renal carcinoma.