These data were unpredictable because H19, as with other cancer-associated lncRNAs, was expected to respond in a synergistic manner upon the pro-tumor stimuli, hypoxia and estrogen, in line with previous results on classical estrogen receptor and HIFs target genes, for example, KDR and EPO (Figure S3 and the work of [39]). The gene discussed is KDR; the disease is cancer.