Although previous data reported that H19 overexpression reduced ITGB3, ITGB5, and ITGA5 in bladder cancer cells [54] and increased ITGB1 and ITGA1 in pancreatic cancer cells [66], the molecular mechanism by which H19 regulates integrin was not elucidated. This evidence concerns the gene ITGB5 and familial pancreatic carcinoma.