On the other hand, since the mitogen-activated protein kinase 1 (MAP3K1) regulates numerous intracellular signalling pathways involved in inflammation and apoptosis, Morrell and colleagues hypothesized that there may be genetic variants of MAP3K1 that can modify self-mediated changes in inflammation and transcriptional regulation and that can be associated with ARDS [40]. Here, MAP3K1 is linked to acute respiratory distress syndrome.