VPS13A and Sepsis: Among the strongest signals in this GWAS, there was a missense and potentially deleterious variant located in VPS13A, which encodes a molecule that is involved in the control of protein cycling through the trans-Golgi network and with an important regulatory role in autophagic degradation [61] Importantly, this GWAS could not validate the results provided by Rautanen and colleagues, although they did not focus exclusively on sepsis due to pneumonia, which may explain the discrepancy [59].