Additionally, the analyses from “Pan Cancer Atlas” projects also reinforced the presence of frequent molecular alterations in previously identified major tumor suppressor genes (TSGs) such as TP53, BRCA1/2, CDKN2A/B, PTEN, and NF1. However, the crosstalk amongst these cataloged oncogenes and tumor suppressor genes, especially in the context of tumor heterogeneity and evolution, remains to be completely understood [8,12]. This evidence concerns the gene PTEN and cancer.