Collectively, these results suggest dual concurrent proliferative and anti-apoptotic activities of HSP27 in PCa cells [93] which has promising clinical implications: patients with low phosphatase and tensin homolog on chromosome 10 (PTEN) expression and subsequent high Akt levels are expected to respond positively to HSP27 inhibitors [19]. The gene discussed is HSPB1; the disease is posterior cortical atrophy.