Derivatives including NVP-AUY922 and NVP-HSP90 displayed similar effects to 17-AAG in terms of protein client degradation and HSP70 upregulation in cultured primary prostate tumors [82]; Nevertheless, both compounds exhibited greater apoptotic and anti-proliferative effects than 17-AGG [82,125]. Here, HSP90AA1 is linked to prostate neoplasm.