For example, expression levels of early endosomal Rabs such as Rab4 and Rab5, the late endosomal Rab7a, and the exocytic Rab27, are upregulated in cholinergic basal forebrain neurons and correlated with cognitive decline in individuals with mild cognitive impairment and AD [77]. The gene discussed is RAB7A; the disease is Alzheimer disease.