This raises new mechanistic possibilities for women’s cancer, including, status of this pathway in women’s cancer; role of RNA-epigenetics on DNA-methylation via DNMT3a; role on the expression and feedback regulatory roles of HER2, HER3, HER4, ER and PR; and role of RNA-epigenetics on DNA-methylation via DNMT3a in breast cancer. This evidence concerns the gene ERBB2 and breast cancer.