PTEN and endometrial cancer: Examples of the involvement of TME components in endometrial cancer include: hormones, pro-inflammatory cytokines and growth factors, marcophages and fibroblasts as well as the status of hypoxia and pH etc. The significance of TME in endometrial cancer is underscored by an observation showing that genetic inactivation of PR in stroma—due to PR’s hypermerhylation—in a PTEN knockout mouse model of endometrial cancer could antagonize PR’s growth inhibitory activity in endometrium [204].