Examples of commonly hypermethylated genes in ovarian cancer include: BRAC1, PTEN, HIC1, E-cadherin, APC, MLH1, HIC1 etc. [108,109,110], cell adhesion genes such as ICAM-1, apoptosis genes such as PAR-4, cell cycle inhibitors p16, TUBB3 [111,112,113,114]. The gene discussed is HIC1; the disease is ovarian carcinoma.