Comparison of the APOE genotype-specific ORs across ethnic groups showed that the magnitude of the effect of the ε3/ε4 on AD risk was similar among EastAs (OR (odds ratio) = 5.0, p = 2.6 × 10−152) and EuroAs (OR = 3.8, p = 2.0 × 10−270), but higher than that for AAs (OR = 2.5, p = 1.3 × 10−35). This evidence concerns the gene APOE and Alzheimer disease.