The clinical significance of RacGAP1 has been widely reported, and its expression in tumors is associated with more aggressive phenotypes in many cancers, including high-grade breast cancer, epithelial ovarian cancer, gastric cancer, colorectal cancer, and hepatocellular carcinoma in the transition from low- to high-invasive disease [15,20,39,41,42]. The gene discussed is RACGAP1; the disease is breast cancer.