In addition to SOD1 mutations, other gene defects have been reported to cause ALS, including senataxin (SETX) [28], alsin [29,30], dynactin [31], synaptobrevin/VAMP (vesicle-associated membrane protein)-associated protein B (VAPB) [32], TDP-43, FUS/TLS [33,34], profilin (PFN1) [35], MATR3, CHCHD10, TBK1, TUBA4A, NEK1, C21orf2, and CCNF [36]. The gene discussed is SETX; the disease is amyotrophic lateral sclerosis.