japonica collected from Peter the Great Bay, Sea of Japan, was also shown to block the membrane transport by P-glycoprotein in ascites of mouse Ehrlich carcinoma cells [62], and to suppress colony formation and proliferation of EGF-driven mouse epidermal JB6 Cl41 P+ cells and of human cervix carcinoma HeLa cells at low micromolar concentrations [61]. Here, EGF is linked to cervical carcinoma.