KLF2 and rheumatoid arthritis: In summary, in this paper we have provided evidence that K/BxN serum-induced arthritic inflammation and pathogenesis, osteoclastic differentiation of monocytes, inflammatory cytokines and factors are significantly elevated both in KLF2 hemizygous mice and in monocyte-specific conditional KLF2 knockout mice, indicating the importance of myeloid KLF2 in RA pathogenesis.