ADGRL3 is a member the latrophilin subfamily of G protein-coupled receptors and has already been implicated in ADHD susceptibility, predicting ADHD severity, disruptive behaviours comorbidity, long-term outcome, response to treatment, and SUD [2,3,6,14,15,16,17,18,19,20,21,74]. The gene discussed is ADGRL3; the disease is attention deficit-hyperactivity disorder.