BLM and neoplasm: Other examples include the inhibition of Werner Syndrome (WRN) helicase (NHEJ/BER) in tumours with mutations in Fanconi anaemia-associated genes (interstrand cross-link repair) or the sensitivity of colorectal cancer cells deficient for the Bloom Syndrome (BLM) helicase (HR) to inhibition of the antioxidant enzyme SOD1 [72].