In fact, glutamine anaplerosis was necessary for glutathione homeostasis in several tumors that exhibit KEAP1 mutation with consequent NRF2 constitutive activation [28,77], including the highly aggressive lung adenocarcinoma bearing co-mutations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) and Liver Kinase B1 [78]. Here, KRAS is linked to lung adenocarcinoma.