This hyperglycemic environment and the emerging hyperinsulinemia promote the hepatic activation of transcription factors such as carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein 1c (SREBP1c), which mediate the expression of genes coding for lipogenic enzymes (e.g., acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and stearoyl-CoA desaturase-1 (SCD-1)) [56,57]. This evidence concerns the gene MLXIPL and Hyperinsulinemia.