CACNA1C and Brugada syndrome: Conversely, a loss-of-function mutation in CACNA1C observed in 10‒15% of patients caused a dramatic reduction in CaV1.2-mediated Ca2+ entry that was associated with ST-segment elevation and increased risk of sudden cardiac death secondary to polymorphic ventricular fibrillation or tachycardia in Brugada syndrome [20].