Six further rare missense variants have been identified in RYR2, mapping the locus to chromosome 1q42‒q43 [50,51] in four independent families with the same clinical manifestations and close to CPVT based on exercise-induced ventricular arrhythmias, high penetrance, and a 1:1 sex ratio. This evidence concerns the gene RYR2 and Ventricular arrhythmia.