Two common single nucleotide polymorphisms in exon 37 of the human RYR2 gene, causing non-conservative amino acid exchanges, i.e., G1885E and G1886S, have been associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) [123]. Here, RYR2 is linked to arrhythmogenic right ventricular cardiomyopathy.