S-phase kinase-associated protein 2 (Skp2) regulates phosphorylated cell cycle regulator proteins and their ubiquitination as a cell cycle regulator and oncogene [29,37], c-Myc also works as an oncogene and cell cycle regulator [38], while PI3K and AKT are considered typical survival proteins in several cancers [39]. This evidence concerns the gene SKP2 and cancer.