It is known that embryonic and cancer cells preferentially use aerobic glycolysis to support proliferation.18, 19 HK2 is mainly expressed in embryonic tissues but less expressed in adult tissues.19 However, HK2, not other HKs, is selectively overexpressed in many tumors, and it plays a critical role in these tumors.19 The overexpression of HK2 in pancreatic cancer was demonstrated to promote pancreatic cancer growth and GEM resistance, thereby providing a new strategy for enhancing the sensitivity to GEM via targeting HK2. Here, HK2 is linked to cancer.