HAdV-C2 infection also led to rapid EGFR phosphorylation at residues Ser1046/1047, which are substrates for the p38-MAPK effector MK2 (mitogen-activated protein kinase-activated protein kinase 2) that is known to be activated by viral cell entry (Fig 6A) [83,84,85,86]. Here, MAPKAPK2 is linked to infection.