As an independent validation for potential CCA biomarkers, we chose 3 candidates that were elevated in CCA in the normal versus CCA comparison (negative p(corr) value in Table 2), lysosome associated membrane glycoproteins 1 (LAMP1), lysosome associated membrane glycoproteins 2 (LAMP2) and cadherin-related protein member 2 (CDHR2). The gene discussed is LAMP2; the disease is cholangiocarcinoma.