Frequencies of HLA-DRpos CD4 T cells were significantly increased in subjects with W. bancrofti infection (n = 33 median: 10.71%) compared to subjects either without any helminth infection (n = 42, median 6.97%, p = 0.016 Mann-Whitney test, univariable analysis, Fig 3A) or the combined group of individuals harboring other helminths (S. haematobium, S. mansoni, T. trichiura, A. lumbricoides, hookworms) (n = 151 median 7.38%, p = 0.009). This evidence concerns the gene CD4 and helminthiasis.