The univariate analysis showed that BMI, congestive heart failure, diabetes mellitus, hypertension, MAP, phosphate (0 h), phosphate (24 h), mechanical ventilation, Hb, Cr, Alb, 2 h urine output at CRRT initiation, APACHE II score, SOFA score and CRRT causes were associated with the 28-day mortality of patients with AKI undergoing CRRT (see Table 2). The gene discussed is ALB; the disease is hypertensive disorder.