One such protein is Cypher, a PDZ and LIM domain‐containing protein, that was first cloned in 1999.15Cypher‐deficient mice display premature lethality with severe DCM and disorganized Z‐lines.16 Furthermore, many mutations in the human Cypher/ZASP gene have been identified in patients with DCM.8 Compared to Cypher, less is known about the role of the other two PDZ‐LIM proteins, ALP and ENH, in the heart. This evidence concerns the gene LDB3 and familial dilated cardiomyopathy.