Functionally, these proteins participate in the formation of sarcomeric complexes at the Z‐line and interact with various proteins through their LIM domains, particularly with signalling factors.9 ALP and ENH are essential for proper heart development and contractility in hearts, as a PDLIM3 or PDLIM5 deficiency in mice results in DCM.9, 10, 17 The important roles of ALP and ENH in heart function make them two promising, candidate genes for cardiomyopathy. The gene discussed is PDLIM3; the disease is cardiomyopathy.