PDLIM3 and myotonic dystrophy type 1: ALP is highly expressed in striated muscle (Xia, 1997).18PDLIM3 resides in chromosome 4q35.1, abnormal splicing of PDLIM3 that is deleted in myotonic dystrophy type 1.19PDLIM3 is a conserved human gene: the EXaC exome aggregation consortium server (http://exac.broadinstitute.org/, accessed as of October 2018) estimates that the frequency of PDLIM3 LOF variants is <1/10 000.