PDLIM5 and familial dilated cardiomyopathy: One such protein is Cypher, a PDZ and LIM domain‐containing protein, that was first cloned in 1999.15Cypher‐deficient mice display premature lethality with severe DCM and disorganized Z‐lines.16 Furthermore, many mutations in the human Cypher/ZASP gene have been identified in patients with DCM.8 Compared to Cypher, less is known about the role of the other two PDZ‐LIM proteins, ALP and ENH, in the heart.