Actinin‐associated LIM protein, highly expressed in skeletal and cardiac muscle, has been suggested to play a pivotal role in myocyte stability, force generation and transmission, signal transduction, and mechanical signalling, especially in growth and remodelling processes.9 As for ENH, cardiac‐specific PDLIM5 knockout mice developed DCM.10 We hypothesized that ALP and ENH, like its homologue Cypher, had an important role in the formation and maintenance of the normal Z‐line in cardiac muscle and are associated with human normal cardiac function. Here, PDLIM5 is linked to familial dilated cardiomyopathy.