Inactivating mutations in cyclin F detected as diploid truncating mutations have been identified in stomach adenocarcinoma, lung adenocarcinoma, medulloblastoma, squamous cell carcinoma of the head and neck, glioblastoma, mucinous adenocarcinoma of the colon and rectum, colon carcinoma and cutaneous melanoma (Cerami et al, 2012; Gao et al, 2013). Here, CCNF is linked to head and neck squamous cell carcinoma.