Moreover, the adverse events such as dysrhythmias, agitation and seizures, observed with doxapram, were only observed with GAL‐053.24, 25, 26, 27 Phase 1 trials with GAL‐054 in healthy volunteers, however, found that GAL‐054 caused hypertension, as previously seen in rat models.27 This evidence concerns the gene GAL and Hypertension.