Tfr cells control the germinal center reaction by limiting the numbers of Tfh cells, their cytokine production and subsequent the humoral response.36, 37, 38 Tfr cells are mainly induced by exposure to self‐antigen to prevent autoimmunity, because defects in Tfr cells lead to spontaneous GC formation and humoral autoimmunity.39 The gene discussed is TFRC; the disease is Autoimmunity.