Sufficient studies have shown that the CKD procalcific environment induces Wnt/β‐catenin pathway activation, which in turn, promotes the development of VC.8, 9, 10, 26 Here, we demonstrated that β‐GP stimulation for 6 hours promoted the phosphorylation of GSK‐3β (Ser9) and β‐catenin (Ser675) (P < .01; Figure 3A). This evidence concerns the gene GSK3B and chronic kidney disease.