The present study has revealed a significant association of three selected ER-β promoter polymorphisms (rs3020449, rs3020450 and rs1271572) between cases and control group in contrary to the study done by Lattrich et al. (2014) in endometrial cancer revealed no significant association of rs3020450 and rs3020449 polymorphism (31). This evidence concerns the gene ESR2 and endometrial cancer.