However, there are no data currently supporting that PAPP-A could be a prognostic factor for preeclampsia because some studies conducted since then support that the difference in the serum PAPP-A is observed only in women with albuminuria (severe preeclampsia); others report no differences between serum PAPP-A levels of women suffering preeclampsia and controls, while others reveal increased concentration in the third trimester [41-46]. Here, PAPPA is linked to preeclampsia.