The same result was observed by Zwahlen et al. in 52 cases of preeclampsia and twice reported in 2009 by Poon et al. in 157 cases with decreased PAPP-A (0.53 MoM and 0.93 MoM) and in another 156 women who developed preeclampsia with low first trimester PAPP-A levels as well (0.555 MoM and 0.911 MoM) [20, 31-33]. This evidence concerns the gene PAPPA and preeclampsia.