In 1983, Wastergaard et al. published a study of three cases reported with the Cornelia De Lange syndrome in which PAPP-A was absent from the maternal serum and trophoblastic tissue, while in the same year, abnormally low levels of PAPP-A were connected to threatened abortion in 51 patients with live fetuses by the time of sampling [7]. The gene discussed is PAPPA; the disease is Cornelia de Lange syndrome.