Reckamp et al. demonstrated the feasibility of urine genotyping using a mutation enrichment next-generation sequencing (NGS) platform to compare the rates of detection of EGFR mutations in both urine and plasma against tissue genotyping in EGFR-mutant NSCLC patients receiving rociletinib in the TIGER-X trial. Here, EGFR is linked to non-small cell lung carcinoma.