Although germline mutations in BRCA family genes are contributed to a high risk of breast and ovarian cancers but are infrequent in Pca cells (0.44% for BRCA1; 1-2% for BRCA2) whereas PTEN inactivation is observed in approximately 70% of primary Pca patients (Cairns et al., 1997[5]). The gene discussed is BRCA1; the disease is ovarian cancer.