In the more recent review article [5], Chang states that “DIC [disseminated intravascular coagulation] has been inappropriately conceptualized as a fibrin clot disease produced via activated TF/FVIIa-initiated cascade/cell-based coagulation” and that “consumption coagulopathy in acute promyelocytic leukaemia that occurs due to pathologic activation of aberrant TF path caused by TF released from leukemic promyelocytes should be called true DIC [8]”. This evidence concerns the gene TF and Disseminated intravascular coagulation.