Previous literature reported that RRM2 promoted tumorigenesis and progression of pancreatic cancer, lung cancer, gastric cancer, ovarian cancer, bladder cancer and other tumors [21–24], TOP2A gene encoded a DNA topoisomerase, it is an ATP-dependent synthetase and hydrolase that plays a key role in cells and plays an important role in many cellular biological processes, such as DNA replication, chromatin condensation, chromosome segregation, and chromosome structure retention. This evidence concerns the gene RRM2 and urinary bladder cancer.