LRG1 and Alzheimer disease: Eight of the 10 genes (BCL6, EFCAB3, IL6, LRG1, PIM1, SERPINE1, SLC11A1, ZBTB16) and two TFs (PPARA and STAT6) were significantly up-regulated in AD (p < 0.05), consistent with the analysis of GSE110226 (Figure 5A).