Activation of EGFR stimulates several downstream signaling cascades, including the RAS/ RAF/MAPK, PI3K/Akt/mTOR, JAK/Src/STAT, and phospholipase C gamma/protein kinase C pathways, triggering oncogene transcription and promoting tumor proliferation, survival, invasion, and drug-resistance [23]. Here, AKT1 is linked to neoplasm.