CRH and major depressive disorder: Elevated levels of CRF were also found in the cerebrospinal fluid (de Bellis, Gold, Geracioti, Listwak & Kling, 1993; Heuser, Bissette, Dettling, Schweiger & Gotthardt, 1998; Nemeroff, Widerlöv, Bissette, Walléus & Karlsson, 1984) and in postmortem brain samples of MDD patients (Austin, Janosky & Murphy, 2003; Bissette, Klimek, Pan, Stockmeier & Ordway, 2003; Raadsheer, Hoogendijk, Stam, Tilders & Swaab, 1994; Wang, Kamphuis, Huitinga, Zhou & Swaab, 2008).