However, patients with low blood IL‐6 and high TNF‐α levels responded well to this antidepressant treatment and showed reduced TNF‐α levels, concomitant with a 50% reduction levels in the Hamilton Depression Rating Scale (HAMD) and in the Montgomery and Åsberg Depression Rating Scale (MADRS), two clinical tools for MDD diagnosis (Lanquillon et al., 2000). This evidence concerns the gene TNF and major depressive disorder.