SOX2 and renal cell carcinoma: As expected, the basal pGL3‐Sox2 activity was higher in RCC cells than that in normal HREpiC cells, and six2‐kd reduced the luciferase activity of pGL3‐sox2 in RCC cells, whereas the activity of pGL3‐sox2‐T27G was unaffected (Fig. 3A–C).