Among these, signaling by Rap1/Rac1 is one of the major pathways controlling cancer cell migration and tumor metastasis.34 Besides, pathways in cancer also play a critical role in CRC metastasis.35 However, more research is warranted to elucidate the precise molecular mechanisms of exosomal miRNAs in mCRC. Here, RAC1 is linked to colorectal carcinoma.