Because the changes in the 3HB serum level are correlated with the ARS-score and the clinical parameters (albumin, prealbumin, BMI and percentage weight loss) reflecting the patients’ treatment related nutritional deficiencies, 3HB may be considered as an indicator of early nutritional disturbances in HNSCC patients during the RT/CHRT treatment. This evidence concerns the gene ALB and head and neck squamous cell carcinoma.