Additional analysis of tumor samples from 126 patients with stage I–IV CRC showed that NRP1-ΔE4 was positively expressed in 71% of CRC tissues and significantly enriched with CRC progression, whereas NRP1-ΔE5 expression was expressed less frequently (25%) and not significantly observed as tumors progressed through stages I–IV (Table 1; Supplementary Table 2). This evidence concerns the gene NRP1 and neoplasm.