NRP1 and colorectal carcinoma: Additionally, intracellular accumulation of endogenous NRP1-∆E4 and NRP1-∆E5 in the primary CRC cell lines (Pt93, Pt2377 and LM2377) was also found in endosomes as demonstrated by co-localization with Rab7 (Supplementary Figs. 2e, 3h).