NRP1 and colorectal carcinoma: Conversely, silencing NRP1 in Pt93 and LM2377 primary CRC cells that express higher levels of endogenous NRP1-∆E4 and/or NRP1-∆E5 than NRP1-WT (Supplementary Fig. 2e) resulted in marked inhibition of cell migration and invasion (Supplementary Fig. 5e-g).