To determine which pathways are involved in the endosomal NRP1 splice variant/Met/β1-integrin complex-promoted CRC cell dissemination, activation of Met and its downstream PI3K/AKT, RAS/ERK and FAK/p130Cas signaling cascades, were examined in HCT116 cells expressing NRP1-WT, NRP1-∆E4, NRP1-∆E5 or vector control. The gene discussed is PTK2; the disease is colorectal carcinoma.