We present several evidences supporting this argument: (i) we demonstrated that stimulation of uninfected donors with anti-CD3 and anti-CD28 antibodies slightly promotes CD20 expression in uninfected CD4+ T cells (up to 4%) (Supplementary Fig. 5b); (ii) LRA treatment slightly increases the expression of CD20 in HIV-negative cells (up to 5%), but the upregulation is stronger in HIV+ cells (up to 20%) (Fig. 8d); and (iii) ex vivo HIV infection of FACS-sorted CD4+CD20− negative cells strongly upregulates CD20 (~30%) (Supplementary Fig. 3). The gene discussed is CD28; the disease is HIV infectious disease.