Remarkably, three clusters (WP-C1, PP-C1, and PP-C2) display similar alteration patterns: Cortex <PDGFRA HGG < NTRK HGG (Fig. 3b, c), and the majority of known glioma pathways are enriched in these three clusters (Fig. 3f), suggesting that NTRK HGG activates similar oncogenic pathways, but with a greater magnitude of response at the global pathway level than PDGFRA HGG. Here, PDGFRA is linked to central nervous system cancer.