Notably, ductal and lobular carcinomas have been observed in Pten+/−;Cdh1+/− compound mice (at approximately 30% incidence) at 6–7 months old, whereas no tumor has been observed in Pten+/− or Cdh1+/− animals at the same age (Fig. 2j, k). Here, PTEN is linked to breast lobular carcinoma.