CDH1 and breast carcinoma: However, different from our previous observation that Cdh1 knockdown led to premature senescence in primary fibroblasts47, in breast cancer cells (Fig. 1 and Fig. 2), although depletion of Cdh1 led a transient growth arrest, cells without Cdh1 eventually gained proliferative advantage over the control cells (Fig. 2a, b and Supplementary Fig. 2a, b).