CDH1 and neoplasm: Conditional knockout of Cdh1 in mice led to the development of epithelial tumors, suggesting a tumor suppressor role for Cdh112, which has been partially attributed to its roles in maintaining genomic stability as well as promoting the ubiquitination and subsequent proteolysis of a number of oncogenic substrates including Plk1, Cdc6, Skp2, and cyclin A11.