This relationship is confirmed by the increase in the levels of circulatory markers associated with inflammation, such as C-reactive protein (CRP), IL-6, TNF-ɑ, interleukin-8 (IL-8), monocyte chemoattractant protein-1(MCP-1), soluble intercellular adhesion molecule-1, and white blood count (WBC) in patients with PCOS [22, 155, 156]. This evidence concerns the gene TNF and polycystic ovary syndrome.