PPARGC1A and polycystic ovary syndrome: Skov et al. discovered that the expression levels of OXPHOS-related genes (NDUFA3, SDHD, UCRC, COX7C, ATP5H, and PGC-1ɑ) and ribosomal proteins in skeletal muscle biopsies collected from women with PCOS and IR are unanimously decreased [100].