Compared with inland centers, coastal centers had a higher use of anti-TNF agents (37.0% vs. 26.2%, p = 0.0123), enteral nutrition (20.5% vs. 3.1%, p < 0.0001), antibiotics (19.2% vs. 3.1%, p < 0.0001), anti-tuberculosis (8.4% vs. 0.5%, p < 0.0001) and other agents including traditional Chinese medicine (35.1% vs. 3.7%, p < 0.0001), but with a lower use of steroids (14.9% vs. 27.7%, p = 0.0005). The gene discussed is TNF; the disease is tuberculosis.