Activated fibroblasts in turn through secretion of fibroblast growth factors, hepatocyte growth factor, interleukin (IL) 6, and TGF-β enhance cancer progression and tumor metastasis (Boimel et al., 2012, Chatterjee et al., 2018, Hugo et al., 2012, Kuperwasser et al., 2004, Pickup et al., 2013, Scherz-Shouval et al., 2014, Sharon et al., 2015). Here, TGFB1 is linked to cancer.