CASR and hypercalcemia disease: Cinacalcet acts as an allosteric activator of CaSR, thereby increasing thesensitivity of CaSR to extracellular calcium and promoting decreased PTH secretionwithout increasing serum calcium and phosphorus levels.11,12Therefore, it can be prescribed even to individuals with hypercalcemia and/orhyperphosphatemia, a situation in which active vitamin D and its analogues arecontraindicated.