Among the recently described mechanisms, one can emphasize the following: i) myeloperoxidase (MPO), a key PMN enzyme, can decrease mortality in a sepsis model and regulate inflammation [5,6], ii) our group and others have described PMN-induced dendritic cell modulation in particular via NETs [7,8], iii) NADPH oxidase 2 (NOX2) can limit inflammation in some situations [9] iiii) several inhibitory receptors and mediators have been described such as immunoglobulin-like transcript 4 or Glucocorticoïd- Induced Leucine Zipper (GILZ) [10,11]. The gene discussed is TSC22D3; the disease is Sepsis.