ABCA1 and Down syndrome: Human high‐density lipoprotein (HDL) deficiencies, such as syndrome sterol deposits and premature atherosclerosis, are caused by ABCA1 mutations.106 In THP‐1 derived foam cells, lincRNA‐DYNLRB2‐2 was distinctly increased, which promoted ABCA1‐mediated RCT and inhibited inflammation response by up‐regulating G‐protein‐coupled receptor (GPR119), and eventually slowed the atherosclerotic plaque formation down.107 Sallam et al have identified the lncRNA MeXis positive regulated the critical cholesterol efflux gene Abca1, which encodes ABCA1 protein.