TNF and viral infectious disease: However, it did not seem to involve in regulating the expression of overlapped IL7R gene and viral infection.73 Similarly, lincRNA THRIL as a negative regulation of NF‐κB could interact with hnRNPL at the Tnfα gene and ensure the expression of TNF‐α in dosage control, but it down‐regulated in human macrophages after TLR2 activation.74, 75 Encoded by the Tnfα loci, lncRNA SeT increased in LPS‐treated murine macrophage,76 with unstable Tnfα mRNA.20 The above lncRNAs are important to reduce TNFα expression in macrophages.