Additionally, lncRNA ENST00000444164 and ENST0000043768 were overexpressed in EOC‐derived exosome and might regain the migration of endothelial cell via NF‐κB phosphorylation.90 In hepatocellular carcinoma (HCC), lncRNA cox‐2 could suppress the tumorigenesis and metastasis by promoting M1‐type macrophage and inhibiting M2 type.56 LncRNA uc.306 was up‐regulated in U937 cells during M2 differentiating to M1 phenotype. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.