NT‐proBNP is another biomarker reflecting right heart function,15 and it is associated with different cardiac markers such as WHO functional class, and hemodynamics.16, 17 Studies showed that NT‐proBNP was significantly associated with prognosis in either idiopathic PAH or PAH‐CHD patients.18, 19 However, single biomarker identifies patients less accurately. This evidence concerns the gene NPPB and pulmonary arterial hypertension.