Though with different mechanisms underling, the pathogenic progress in PAH subgroups are similar because most patients die because of the right heart failure at the end stage.22 The independent prediction of prognosis by 6MWD and NT‐proBNP in our study expanded the value of these two parameters in risk assessment for PAH‐CHD, and further strengthened the critical role of right heart function for PAH patients regardless their subgroups. This evidence concerns the gene NPPB and pulmonary arterial hypertension.